注射型磷酸鈣骨水泥/纖維蛋白膠作為BMP注射性載體的可行性研究

注射型磷酸鈣骨水泥/纖維蛋白膠作為BMP注射性載體的可行性研究

作者：劉通方,劉建,孟國林,袁志,呂榮,畢龍,王登虎,劉艷武,胡蘊玉
【關鍵詞】 注射劑；磷酸鈣類；骨粘合劑；纖維蛋白組織粘著劑；骨形態發生蛋白質類；載體；骨誘導
　 【Abstract】 AIM: To evaluate the feasibility of injectable calcium phosphate cement (ICPC) and fibrin sealant (FS) as an injectable compound carrier of bone morphogenic protein (BMP) . METHODS: The composites of ICPC/FS/bBMP, ICPC/FS or bBMP were injected subcutanously or implanted into thigh muscle pouches of 45 mice at random.The effect of ectopic bone formation was evaluated by biochemical examination of alkaline phosphatase (ALP) and histological examination 2 and 4 weeks after operation and the new bones were weighed in the 4th postoperative week to compare statistically the ability of bone formation of different composites. RESULTS: ICPC/FS/bBMP composite induced the formation of new bone most effectively. BBMP stimulated cess osteogenesis while ICPC/FS showed no sign of new bone formation.There was a significant difference among them (P

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