過熱對脂多糖介導的大鼠急性肺損傷/急性呼吸窘迫綜合征的影響

過熱對脂多糖介導的大鼠急性肺損傷/急性呼吸窘迫綜合征的影響

作者：林曉靜，鄒飛，李亞潔，王斌，韓雪琳，賀文靜
【關鍵詞】 急性肺損傷
Aggravating effect of hyperthermia on lipopolysaccharidemediated ALI/ARDS in rats
　　【Abstract】 AIM: To observe the effect of hyperthermia on lipopolysaccharide (LPS)mediated ALI/ARDS in rats. METHODS: Male specificpathogen free Wistar rats were randomly assigned to the following groups: salineinjected normothermic control (CGroup), salineinjected heat exposed (HGroup), LPSinjected normothermic control (LGroup) and LPSinjected heat exposed (HLGroup). Rectal temperature (Tr) was continually monitored. Plasma levels of TNFα and IL6, arterial blood gas, lung wettodry weight ratio (W/D), and lung histological change were observed at 0, 40, 80 and 120 min. RESULTS: ① The rats in HLGroup displayed significantly higher values of Tr (43.04±0.11) ℃ compared with C/LGroup （P

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